Effect of maternal protein and vitamin B12 supplementation on placental vasculature
The cause of intrauterine growth retardation (IUGR) is multi-factorial, and a number of nutrients have critical roles in contributing to an optimal birth outcome. Low maternal vitamin B12 status during pregnancy has been reported to be associated with higher risks of IUGR. However, the mechanism for this association has not been elucidated.
The current project is based on the hypothesis that maternal vitamin B12 intake and status affects fetal growth by modulating placental expression of genes critical for appropriate formation and development of the placental vasculature. Insights gleaned from these investigations are likely to prove crucial for designing population-specific nutritional intervention strategies for improving birth outcome.