St. John's Research Institute

Division Non Division User Project / Title DBT Cardinnate Study Project

Contact Person Mrs. Lincy Thomas Contact No 080-49467010/7011/7021

Brief Description about the Project 

IMPORTANCE Proposal Hypothesis: Variation in innate immune activation and attendant cardiac damage and dysfunction collectively drive systemic immunopathology and account for the differences in COVID-19 mortality between SAs in the UK and India. Specific Aims to Address this Hypothesis 1. Assess the differences in pre-existing health conditions, disease severity and the pattern of in-hospital complications between SAs admitted with COVID-19 in the UK versus India to determine the contribution of pre-existing CVD/diabetes and cardiac dysfunction. Approach: Retrospective analyses of existing clinical and imaging datasets in both countries. 2. Determine whether there are inherent differences in microbially-induced proinflammatory and antiviral immune responses between SAs in UK versus India, and their association with CVD and autoantibodies to IFN. Approach; Study of non-infected subjects with a range of CV risk factors. 3. Perform extensive systemic immunophenotyping, and analysis of endothelial, complement activation, and cardiac function in SAs admitted with severe COVID-19 in London and India to identify key immune patterns / signatures associated with clinical outcome. Approach: Prospective study in patients hospitalised with severe COVID-19. 4. Determine the inter-relationship between immune responses, pre-existing CVD and functional outcome in SAs who have recovered from COVID19 in the UK versus India. Approach: Add-on analyses in recovered COVID-19 patients being monitored at 6-9 months post-discharge.

Senior Project Associate

Position Starting: 01^st April, 2023

No. of Vacancy: One

Employment status: Contract

Salary: As per qualifications and experience

Preferred Language: English

Preferred Qualifications: Junior Research Fellow (JRF)

Post Graduate Degree in Basic Science OR Graduate / Post Graduate Degree in Professional Course selected through a process described through any one of the following:

Scholars who are selected through, National Eligibility Tests- CSIR-UGC NET including lectureship (Assistant Professorship) and Gate.

The selection process through National level examinations conducted by Central Government Departments and their Agencies and Institutions such as DST, DBT, DAE, DOS, DRDO, MHRD, ICAR, ICMR, IIT, IISc, IISER etc.

Or

Master’s Degree in Natural or Agricultural Sciences / MVSc or Bachelor’s degree in Engineering or Technology or Medicine from a recognized University or Equivalent

Experience: MSc in Immunology with 1 year experience gained through a master’s project

Last Day for Receiving Application: 25^th March, 2023

Roles and Responsibilities:

• To conduct primary research as per the CARDINNATE award, including research towards stated goals and exploratory research within the confines of the BIRAC award in consultation with Dr Vyakarnam
• To work under supervision of Lead Project Scientist of BIRAC project in set up of immune assays and processing of clinical samples.
• To undertake key scientific administrative duties in placing ordering and maintaining an overview of expenditure
• To communicate work plan and data in weekly scientific laboratory meetings 5. To undertake scholarly research activities such as scientific literature analysis and to show keenness to keep abreast of the current field and to effectively communicate academic thinking.

 

Interested candidates may send their Resume to:

The Principal Investigator

DBT Cardinnate Study Project

SJMC

 

To Apply: E-mail cover letter and curriculum vitae with 3 references (names and email addresses / phone numbers) by on or before 25^th March, 2023  yashashwini@sjri.res.in    and cc to hr@sjri.res.in

For more information, please visit our website www.sjri.res.in

 

Can Contact us on the following Numbers 080-49467010/49467011