My team is focused on understanding human disease biology in order to develop new molecular targets and biomarkers. Identification of newer molecular targets with potential to be developed into therapeutic targets is key towards developing personalized treatment for a heterogonous disease like cancer. Thus, it is essential to understand the role of various signalling pathways in cancer stem cell maintenance in order to develop new therapies suited to the patients. Similarly understanding the molecular mechanism of heterogeneity in response to therapy including diseases like Hemophilia and Cancer is the focus of the laboratory.
RhoC regulates radioresistance in cervical cancer via ROCK2 mediated DNA repair. Annapurna P, M.Sc; Pavana Thomas, M.Tech; Avinash H Udayashankar; Chandra Bhavani; Srinag Bangalore Suresh; Sudhir Krishna; Jayashree Thatte; Nirmala Srikantia; Cecil Ross; Sweta Srivastava. Journal of Experiment and Clinical Cancer Research, 2019, 38, 392.
RhoC: A fascinating hourney from a cytoskeletal organizer to a cancer stem cell therapeutic target. Pavana Thomas and Sweta Srivastava, Journal of Experimental and Clinical Cancer Research, 2019, 38, 328.
Ally to adversary: Mesenchymal stem cells and their transformation in leukemia. Mugdha Sharma, Cecil R Ross, Sweta Srivastava. Cancer Cell International. 2019, 19, 139.
An ingenious non-spherical mesoporous silica nanoparticle cargo with curcumin induces mitochondria-mediated apoptosis in breast cancer (MCF-7) cells. Harini L, Sweta Srivastava, et al. Oncotarget, 2019, 10, 1193.
Circulating Nucleic Acids: An analysis of their occurrence in malignanices? Shankar Suraj PG, Dhar Chirag and Srivastava Sweta. Biomedical Reports, 2017, 6, 8.
Cancer stem cells and radio-resistance- Rho/ROCK pathway plea attention. Annapurna Pranatharthi, Cecil Ross, and Sweta Srivastava. Stem Cells Int. 2016:5785786.
Role of RhoC in cervical cancer stem cell maintenance
Understanding the role of ROCK signaling in radioresistance
Role of Immune response in hemophilia A therapy response
Role of derivative chromosome in Chronic myeloid leukemia progression
Identifying natural ingredient based novel radiosensitizers