Although interaction between glomerular cells and monocytes are known, their role in the progression of CKD remains unclear. Our studies would help identify putative mechanisms of monocyte-dependent progression of CKD. Phenotypic and functional characterization of monocyte subsets will improve our understanding of the mechanisms mediating inflammation in CKD. It will also help understand inflammation and its cascading effects on the development of renal and cardiovascular disease, anemia, malnutrition and bone mineral disease. The functional studies would help us identify novel mediators of inflammation in CKD and provide us targets for the development of novel therapeutic strategies to mitigate progression of renal disease and its associated complications.