SJRI | St. John's Research Institute

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Sl No.	Project Title	Project Lead	Year
1	Evaluating role of circulating DNA as biomarkers of tumor progression and response to therapy in neo-adjuvant setting of breast cancer	Dr. Rakesh S Ramesh; Co-PI-Dr. Madhumathy Nair	2020-2022
2	Breast Cancer in Pre-menopausal women- Evaluation of the role of steroid hormones in resistance to therapy	Dr Jyothi S Prabhu	2019-2024
3	Evaluating the role of miR-18a regulating metastatic progression of Breast Cancer	Dr Madhumathy G Nair	2019-2022
4	To investigate the role of miR-18a in regulating metastatic progression of breast cancer	Dr. Madhumathy G Nair	2019
5	Circulating microRNA a novel prognostic and diagnostic biomarker of pre diabetes, Type 2 diabetes and its complications among Indians	Dr Jyothi S Prabhu	2018-2020
6	Evaluation of expression of chosen set of markers by immuno histochemistry on the tissue micro array (TMA) blocks of colorectal cancer (CRC)	Dr. Jyothi S Prabhu	2018
7	Expression of Human Epidermal Growth factors (HER) family of proteins in Ovarian Carcinomas and their relation to clinic pathological factors	Dr. Jyothi S Prabhu	2016
8	Investigating the role of BLM helicase as a global tumor suppressor: Clinical Applications	Dr. Jyothi S Prabhu	2015
9	Denmark India in vivo screen for Cancer Biomarkers	Dr. TS Sridhar	2014
10	Examination of mechanobiology of ER negative breast cancer tumors in Indian women	Dr. TS Sridhar	2012
11	Breast Cancer Patient Support Group Activities	Dr. TS Sridhar	2009
12	Prospective longitudinal study of breast cancer	Dr. TS Sridhar	2008

Sl No.	Project Title	Project Lead	Year
1	DBT-BBI Phase-II Programme	Dr. Amit K Mandal, Dr. Limesh M, Dr. Mahesh Jayachandra	2018
2	Analysis of Hemoglobin Variants (In collaboration with IISc)	Dr. Amit Kumar Mandal	2012
3	Structural proteomics of glutathionylation and glycation of erythrocyte proteome: A focus on glutathionylated and glycated hemoglobin	Dr. Amit Kumar Mandal	2012
4	Identification of a biomarker for prostate cancer using mass spectrometry based urine proteomics	Dr. Amit Kumar Mandal	2012
5	The development of proteomic markers to detect early iron overload with different dietary supplementation strategies using ferrous pyrophosphate in its nano form	Dr. Amit Kumar Mandal	2012
6	Identification, characterization and quantification of glutathionylated proteins in cerebrospinal fluid using mass spectrometric based proteomics in patients with multiple sclerosis	Dr. Amit Kumar Mandal	2012
7	Identification and characterization of hemoglobin variants using mass spectrometry	Dr. Amit Kumar Mandal	2011
8	Structural comparison of normal haemoglobin, HbA and a variant haemoglobin, HbE to assess the functional differences	Dr. Amit Kumar Mandal	2011
9	Mass spectrometry based plasma proteomics in patients with attempted suicide (In collaboration with Dr. K Srinivasan)	Dr. Amit Kumar Mandal	2010

Sl No.	Project Title	Project Lead	Year
1	Enumeration of osteoclasts derived from monocyte subsets and its association with chronic kidney disease	Dr. Anbazhagan Kolandaswamy	2018
2	NephroS International: Transnational cohorts of nephritic syndrome - A unified approach to a global chronic disease	Dr. Anil Vasudevan	2017
3	Genetic and cellular correlates to Lowe’s oculocerebro-renal syndrome (OCRL) in the Indian population	Dr. Anil Vasudevan	2017
4	Mutation screening in children with congenital anomalies of the kidney and urinary tract (CAKUT) using Next-generation sequencing (NGS) platform	Dr. Anil Vasudevan	2016
5	Pediatric Renal Biology Program Research on Nephrotic Syndrome	Dr. Anil Vasudevan	2016
6	Phenotypic and functional characterisation of monocyte subsets in chronic kidney disease and its impact on progression of disease and associated complications	Dr. Anbazhagan Kolandaswamy	2016
7	Molecular Basis of Nephrotic Syndrome	Dr. Anil Vasudevan	2015
8	Biomarkers for early detection and prognosis of sepsis associated acute kidney injury	Dr. Anil Vasudevan	2015
9	Programme support on the effect of aminoacids, vitamin A on fetal growth, placental function and low birth weight	Dr. Anil Vasudevan	2013

Sl No.	Project Title	Project Lead	Year
1	Shh signaling in cancer progression and drug-resistance	Dr. Sitalakshmi Subramanian and Dr. Neha Vyas	2017
2	Exovesicular release of Hedgehog and miRNA packaging	Dr. Neha Vyas	2016

Sl No.	Project Title	Project Lead	Year
1	A study to evaluate the Vit D receptors and their signaling pathways in skeletal muscle among Indians with type 2 diabetes	Dr Jyothi S Prabhu	2018-2020
2	Clinical and molecular landscapes of triple negative breast cancer in India and application to improved treatment decisions.	Dr Aruna Korlimarla	2018-2019
3	Evaluation of expression of Specified set of marker by Q-RT- PCR on tumor specimens belonging to the breast cancer cohort	Dr Aruna Korlimarla	2018- 2019
4	A retrospective pilot study of analysis of Breast tumors from Lymph node metastasis for evaluation of metastatic potential to distant organ compared to matched primary breast cancer	Dr Gnanapriya Sivakumar/ Dr. Aruna Korlimarla	2017-2019
5	Evaluation of expression of chosen set of markers by immunohistochemistry on tissue micro array (TMA) blocks of colorectal cancer	Dr Jyothi S Prabhu	2017-2018
6	Functional, morphological, microscopic and molecular characterization of placentae in normal and IUGR pregnancies, in a south Indian cohort	Dr. Anura Kurpad/ Dr. Julian Crasta/ Dr. T.S. Sridhar	2013-2018

Sl No.	Project Title	Project Lead	Year
1	Miniaturized Electrochemical Cell Platform for Monitoring of Glycated Hemoglobin	Dr. Amit Kumar Mandal	2012
2	Ferric Pyrophosphate Nanoparticles: Feasibility, Bioavailability & Toxicity Assessments	Dr. Amit Kumar Mandal, Dr. Arun Shet, Dr. Anura V Kurpad	2012
3	Extra cellular proteome profiling of Staphylococcus aureus (In collaboration with IISc and Dr. John Kenneth)	Dr. Amit Kumar Mandal	2010
4	Proteomic characterization of post translational modifications of hemoglobin in Iron deficiency anemia and Iron overload	Dr. Amit Kumar Mandal, Dr. Arun Shet	2009
5	Structural biology of glutathionyl BSA, a model system of post translation modification under oxidative stressed condition	Dr. Amit Kumar Mandal	2009
6	Folding study of amyloid beta protein using fluorescence, circular dichroism and nuclear magnetic resonance spectroscopy	Dr. Amit Kumar Mandal	2009
7	Proteomic characterization of post translational modifications of hemoglobin in Iron deficiency anemia and Iron overload	Dr. Amit Kumar Mandal, Dr. Arun Shet	2009

Sl No.	Project Title	Project Lead	Year
1	NPH2 (podocin) and wt1 (Wilms' tumor gene1) mutations in indian children with sporadic idiopathic steroid resistant nephrotic syndrome	Dr. Anil Vasudevan	2013
2	Lipid profile in idiopathic nephrotic syndrome in children	Dr. Kishore Phadke	2012
3	Are human gene variants in Vitamin A Metabolic Pathway associated with Newborn Kidney Size and Function	Dr. Anil Vasudevan	2012
4	Use of accurate tracer based approaches to assess vitamin A pool size in children and pregnant women	Dr. Anil Vasudevan	2012
5	Podocin mutations in Indian children with primary idiopathic steroid resistant syndrome	Dr. Anil Vasudevan	2011
6	To identify polymorphisms in the coding or regulatory sequences of Retinol metabolism genes associated with low newborn all-trans retinoic acid level and/or subtle renal hypoplasia	Dr. Kishore Phadke, Dr. Anil Vasudevan	2011
7	Evaluation and Validation of High-Resolution Melting Analysis as a cost effective and efficient tool for detecting Single-Nucleotide Polymorphisms	Dr. Anil Vasudevan	2010
8	Acute Kidney injury in Children Admitted to a Tertiary PICU: A Preliminary study of Incidence, Risk factors and Outcomes	Dr. Anil Vasudevan	2009
9	Effects of Maternal Vitamin A deficiency on kidney development in Newborns	Dr. Anil Vasudevan	2008
10	Evaluation of Urinary Biomarkers (NGAL, KIM 1 and IL 18) for early detection and prognosis of Acute Kidney Injury in Critically Ill Children	Dr. Kishore Phadke, Dr. Anil Vasudevan	2008

Sl No.	Project Title	Project Lead	Year