A study by immunologists from St John’s Research Institute (SJRI) has found that Bacille Calmette-Guerin (BCG) revaccination in adults enhanced pro-inflammatory markers of trained immunity along with anti-inflammatory pathways. The study was published in iScience, a peer-reviewed scientific journal last month.
Publication: This study characterized mechanisms of BCG revaccination-induced trained immunity (TI) in India. Data highlights a balanced immune response comprising pro- and anti-inflammatory mediators is a feature of BCG revaccination-induced immunity. Ahmed, A., Tripathi, H., van Meijgaarden, K.E., Kumar, N.C., Adiga, V., Rakshit, S., Parthiban, C., Eveline J, S., D'Souza, G., Dias, M., Ottenhoff, T.H.M., Netea, M.G., Joosten, S.A., Vyakamam, A., BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways,
ISCIENCE (2023), doi : https://doi.org/10.1016/j.isci.2023.107889