POISE-3 - Peri-Operative ISchemic Evaluation-3

An Investigator Initiated Multicentre, international, randomized controlled trial of tranexamic acid (TXA) versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance strategy.

The study aims to determine if TXA is superior to placebo for the occurrence of life-threatening, major, and critical organ bleeding, and non-inferior to placebo for the occurrence of major arterial and venous thrombotic events.

It also aims to assess the impact of a hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of vascular death and major vascular events in patients  after non-cardiac surgery.

Sample Size (Global & Indian):
Global - 10,000 patients
India - 600

Study Update: 6795 patients recruited in total from 99 activated centres globally.  From India, 475 patients randomized into study.                                                                       

                                                                                                                                                                                                        Updated as of 3rd Sep, 2020

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