> An Investigator Initiated Multicentre, international, randomized controlled trial of tranexamic acid (TXA) versus placebo and, using a partial factorial design, of a perioperative hypotension-avoidance versus hypertension-avoidance strategy.
> The study aims to determine if TXA is superior to placebo for the occurrence of life-threatening, major, and critical organ bleeding, and non-inferior to placebo for the occurrence of major arterial and venous thrombotic events.
> It also aims to assess the impact of a hypotension-avoidance strategy versus a hypertension-avoidance strategy on the risk of vascular death and major vascular events in patients after non-cardiac surgery.
Sample Size (Global & Indian):
> Global - 10,000 patients
> India - 600
Study Update: 6795 patients recruited in total from 99 activated centres globally. From India, 475 patients randomized into study.
Updated as of 3rd Sep, 2020