Projects

ACT Study - Anti-Coronavirus Therapies (ACT) to prevent progression of COVID-19: Randomized trials
Details

a) Background:

COVID-19 is a global pandemic. Various treatments have the potential to prevent disease progression but so far few have been proven to be effective.

b) Aim

This program will evaluate anti-inflammatory and anti-thrombotic therapy to determine whether they prevent clinical progression of mild COVID-19

c) Objectives:

  • Colchicine vs. Control prevents progression to moderate/severe disease requiring hospitalization or death (primary) or disease progression by 2 points on a 7-point scale (co-primary).
  •  ASA vs. control prevents progression to moderate/severe disease requiring hospitalization or death (primary), the composite of major adverse cardiovascular events (MI, stroke, ALI, VTE, death) (co-primary) or disease progression by 2 points on a 7-point scale (co-primary).

d) Sample size:

Global -3500 / India 300

e) Study update:

India has randomized 77 patients

Updated as on: 27 Apr 2022

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