Analysis of Clinico-Pathological Characteristics of Indian Breast CancersShows Conservation of Specific Features in the Hormone Receptor Sub-Types

Authors : Mukherjee G, Lakshmaiah KC, Vijayakumar M, Prabhu JS, Telikicherla D, Sridhar TS, Kumar RV

Publication Year : 2016

Abstract :


Clinical epidemiology studies of breast cancer in India have reported younger age at detection, presentation at a later stage with a greater proportion of Triple Negative Breast Cancer (TNBC). The aim of this study was to examine the standard clinic-pathological variables in the hormone-receptor based sub-types for patterns indicative of intrinsic differences from that reported in Western, Caucasian women.


Clinico-pathological variables from 645 patients who were diagnosed with breast cancer during 2012 at the regional cancer were retrospectively analyzed for clinical and immunohistochemistry details.


The median age at first diagnosis is 48 years which is decade earlier than that reported in Western case-series, 65% were lymph-node positive, and 33% of all cases were Triple negative Breast Cancers. Sub-type specific examination of tumor size and lymph-node (LN) status showed the HER2 positive tumors to have the highest proportion of tumors that were pT4 and 75% were LN positive. Conversely, despite 92% of TNBCs being grade 3, 40% of them were LN negative.


We confirm the three cardinal clinical epidemiological features reported by other Indian centres. The clinical behavior of the HER2 positive and TNBC sub-types are no different from that reported in Western case series suggesting that these aspects are innate and conserved.