Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children

Authors : Jenum S, Dhanasekaran S, Ritz C, Macaden R, Doherty TM, Grewal HM; TB Trials Study Group

Publication Year : 2016

Abstract :

We have explored the added value of interferon-? (IFN?)-inducible protein 10 as a read-out of Mycobacterium tuberculosis-specific immunity in young Indian children, where the sensitivity of the IFN? release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFN?/inducible protein 10 read-out in a 4th generation IFN? release assays.