Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study

Authors : Andrew Smyth, Conor Judge, Xingu Wang, Guillaume Pare, *Denis Xavier*, Sumathy Rangarajan, Michelle Canavan, Siu Lim Chin, Fawaz Al-Hussain, Afzalhussein M Yusufali, Ahmed Elsayed, Albertino Damasceno, Alvaro Avezum, Anna Czlonkowska, Annika Rosengren, Antonio L Dans, Aytekin Oguz, Charles Mondo, Christian Weimar, Danuta Ryglewicz, Fernando Lanas, German Malaga, Graeme J Hankey, Helle K Iversen, Hongye Zhang, Khalid Yusoff, Nana Pogosova, Patricio Lopez-Jamarillo, Peter Langhorne, Rafael Diaz, Shahram Oveisgharan, Salim Yusuf, Martin O'Donnell, INTERSTROKE investigators

Publication Year : 2021

Abstract :


Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association.


We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations.


INTERSTROKE is a case-control study and the largest international study of risk factors for first acute stroke, completed in 27 countries. We included individuals with available serum creatinine values and calculated estimated glomerular filtration rate (eGFR). Renal impairment was defined as eGFR <60>


Of 21,127 participants, 41.0% were female, the mean age was 62.3 ± 13.4 years, and the mean eGFR was 79.9 ± 23.5 mL/min/1.73 m2. The prevalence of renal impairment was higher in cases (22.9% vs. 17.7%, p < 0>


Renal impairment is an important risk factor for stroke, particularly in younger patients, and is associated with more severe stroke and worse outcomes.