Infectious Diseases


The tuberculosis (TB) epidemiological studies were conducted at the Palamaner field site in Chittoor District, Andhra Pradesh, set up under a programme approved by the Ministry of Health Screening Committee, Government of India. The studies were funded by the Aeras Global TB Vaccine Foundation, USA, and the Research Council of Norway. Three large cohort studies assessed cumulative incidence of TB in 1) newborns followed for 2 years, 2) adolescents aged 12 to <18 years followed for 2 years and 3) household contacts of smear positive TB index cases followed for a year. Apart from epidemiological analyses, the studies will also contribute to the evaluation of biomarkers in latent TB infection and TB disease.

Sl No. Title Authors Journal Name Publication Year
1 Identification of subclinical tuberculosis in household contacts using exposure scores and contact investigations Bekken GK, Ritz C, Selvam S, Jesuraj N, Hesseling AC, Doherty TM, Grewal HMS, Vaz M, Jenum S BMC Infect Dis 2020
2 Moraxella catarrhalis: A Cause of Concern with Emerging Resistance and Presence of BRO Beta-Lactamase Gene-Report from a Tertiary Care Hospital in South India Raveendran S, Kumar G, Sivanandan RN, Dias M Int J Microbiol 2020
3 Current state of the art in rapid diagnostics for antimicrobial resistance Shanmugakani RK, Srinivasan B, Glesby MJ, Westblade LF, Cárdenas WB, Raj T, Erickson D, Mehta S Lab Chip 2020
4 Pathogen genomic surveillance of typhoidal Salmonella infection in adults and children reveals no association between clinical outcomes and infecting genotypes Britto CD, Mathias S, Bosco A, Dyson ZA, Dougan G, Raveendran S, Abin VL, Jose S, Nagaraj S, Holt KE, Pollard AJ Trop Med Health 2020
5 Plasma metabolomic study in perinatally HIV-infected children using 1H NMR spectroscopy reveals perturbed metabolites that sustain during therapy Kaur S U, Oyeyemi BF, Shet A, Gopalan BP, D H, Bhavesh NS, Tandon R PLoS One 2020
6 Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomes Sivakumaran D, Jenum S, Vaz M, Selvam S, Ottenhoff THM, Haks MC, Malherbe ST, Doherty TM, Ritz C, Grewal HMS Commun Biol 2020
7 Is a differentiated care model needed for patients with TB? A cohort analysis of risk factors contributing to unfavourable outcomes among TB patients in two states in South India Washington R, Potty RS, Rajesham A, Seenappa T, Singarajipura A, Swamickan R, Shah A, Prakash KH, Kar A, Kumaraswamy K, Prarthana BS, Maryala BK, Sushma J, Dasari R, Shetty B, Panibatla V, Mohan HL, Becker M BMC Public Health 2020
8 Using data from 'visible' populations to estimate the size and importance of 'hidden' populations in an epidemic: A modelling technique Foss AM, Prudden HJ, Mitchell KM, Pickles M, Washington R, Phillips AE, Alary M, Boily MC, Moses S, Watts CH, Vickerman PT Infect Dis Model 2020
9 Tuberculosis notification in a private tertiary care teaching hospital in South India: a mixed-methods study Siddaiah A, Ahmed MN, Kumar AMV, D'Souza G, Wilkinson E, Maung TM, Rodrigues R BMJ Open 2019
10 Evidence for highly variable, region-specific patterns of T-cell epitope mutations accumulating in Mycobacterium tuberculosis strains Ramaiah A, Nayak S, Rakshit S, Manson AL, Abeel T, Shanmugam S, Sahoo PN, John AJUK, Sundaramurthi JC, Narayanan S, D'Souza G, von Hoegen P, Ottenhoff THM, Swaminathan S, Earl AM, Vyakarnam A Front Immunol 2019
11 Measuring adherence to antiretroviral therapy via hair concentrations in India Gandhi M, Devi S, Bacchetti P, Chandy S, Heylen E, Phung N, Kuncze K, Okochi H, Kumar R, Kurpad AV, Ekstrand ML J Acquir Immune Defic Syndr 2019
12 Increased monocyte activation with age among HIV-infected long term non-progressor children: implications for early treatment initiation D'Souza RR, Gopalan BP, Rajnala N, Phetsouphanh C, Shet A HIV Med 2019
13 Analysis of dengue specific memory B cells, neutralizing antibodies and binding antibodies in healthy adults from India Gunisetty S, Nayak K, Chandra Rai R, Chawla Y, Reddy ES, Aggarwal C, Maheshwari D, Panda H, Ansari NA, Singh P, Kaur M, Dixit K, Sharma P, Bhatnagar P, Priyamvada L, Bhaumik SK, Ahamed SF, Vivek R, Ray P, Shet A, Coshic P, Lodha R, Kabra SK, Afroze D, Yousuf A, Ahmed R, Murali-Krishna K, Chandele A Int J Infect Dis 2019
14 Emergence of new genotypes and lineages of dengue viruses during the 2012-15 epidemics in southern India Ahamed SF, Rosario V, Britto C, Dias M, Nayak K, Chandele A, Kaja MK, Shet A Int J Infect Dis 2019
15 Viral evolution in the cell-associated HIV-1 DNA during early ART can lead to drug resistance and virological failure in children Gopalan BP, D'Souza RR, Rajnala N, Arumugam K, Dias M, Ranga U, Shet A J Med Virol 2019