St. John's Research Institute

Post : Project Scientist III

Qualification : PhD with minimum 5 years postdoctoral experience in Bioinformatics and Immunoinformatics with first author publications or significant and defined role in joint publications

No. of Vacancy : One

Language : English, Kannada,

Location : Bangalore, Karnataka

Application due date : 22nd February, 2022

Salary : Rs. 78,000+24%HRA

Brief Description about the Project:

IMPORTANCE Proposal Hypothesis: Variation in innate immune activation and attendant cardiac damage and dysfunction collectively drive systemic immunopathology and account for the differences in COVID-19 mortality between SAs in the UK and India. Specific Aims to Address this Hypothesis 1. Assess the differences in pre-existing health conditions, disease severity and the pattern of in-hospital complications between SAs admitted with COVID-19 in the UK versus India to determine the contribution of pre-existing CVD/diabetes and cardiac dysfunction. Approach: Retrospective analyses of existing clinical and imaging datasets in both countries. 2. Determine whether there are inherent differences in microbially-induced proinflammatory and antiviral immune responses between SAs in UK versus India, and their association with CVD and autoantibodies to IFN. Approach; Study of non-infected subjects with a range of CV risk factors. 3. Perform extensive systemic immunophenotyping, and analysis of endothelial, complement activation, and cardiac function in SAs admitted with severe COVID-19 in London and India to identify key immune patterns / signatures associated with clinical outcome. Approach: Prospective study in patients hospitalised with severe COVID-19. 4. Determine the inter-relationship between immune responses, pre-existing CVD and functional outcome in SAs who have recovered from COVID19 in the UK versus India. Approach: Add-on analyses in recovered COVID-19 patients being monitored at 6-9 months post-discharge.

Key Skills

• The ability to undertake high end Bioinformatic analysis and data interpret immune functional data derived by RNA Sequence Analysis of bulk immune cells; single cell transcriptome analysis; CHIP-Seq analysis; SNP analysis and T cell and B cell repertoire analysis
• Ability to work independently and be collegiate within a wider team of immunologists.
• Evidence of demonstrable scientific leadership skills with first author publications in field of research with impact and keenness to progress towards an independent researcher status.
• Ability to communicate and interpret scientific literature and primary data using a variety of appropriate software
• Evidence of having undertaken scientific administrative duties including ordering consumables, awareness of financial records and supervising junior staff

Core Responsibilities:

• To conduct primary research as per the CARDINNATE award in the context of Bioinformatic analysis of immune data
• To manage junior staff appointed to the project in conjunction with the PI
• To undertake key scientific administrative duties in placing ordering and maintaining an overview of expenditure
• To communicate work plan and data in weekly scientific laboratory meetings
• To undertake scholarly research activities such as scientific literature analysis to keep abreast of the current field and to effectively communicate academic thinking

Specific Activities

• To plan, set up and execute scientific data analysis in conjunction with discussions with the PI
• To train support staff
• To undertake forward thinking research plans through literature analysis and to test fresh hypothesis.
• To place orders for consumables and maintain records of finance expenditure
• To effectively communicate with staff members of the wider department at SJRI and provide an oversight of the overall science

To Apply : E-mail cover letter, CV, the names & contact details of Referees

To yashashwini@sjri.res.in cc hr@sjri.res.in

For more information please visit our website www.sjri.res.in

Can Contact us on the following Numbers 080-49467010/49467011