Authors : Amit X Garg, Maura Marcucci, Meaghan S Cuerden, Jessica M Sontrop, Thomas W Painter, Vladimir Lomivorotov, Daniel I Sessler, Matthew TV Chan, Flavia K Borges, Kate Leslie, Emmanuelle Duceppe, Chirag R Parikh, Pavel Roshanov, María José Martínez-Zapata, Chew Yin Wang, *Denis Xavier*, Jessica Spence, Thomas Van Helder, Richard Whitlock, Pj Devereaux, et al…
Publication Year : 2024
Background: Most patients who take antihypertensive medications continue taking them on the morning of surgery and during the perioperative period. However, growing evidence suggests this practice may contribute to perioperative hypotension and a higher risk of complications. This protocol describes an acute kidney injury substudy of the Perioperative Ischemic Evaluation-3 (POISE-3) trial, which is testing the effect of a perioperative hypotension-avoidance strategy versus a hypertension-avoidance strategy in patients undergoing noncardiac surgery.
Objective: To conduct a substudy of POISE-3 to determine whether a perioperative hypotension-avoidance strategy reduces the risk of acute kidney injury compared with a hypertension-avoidance strategy.
Design: Randomized clinical trial with 1:1 randomization to the intervention (a perioperative hypotension-avoidance strategy) or control (a hypertension-avoidance strategy).
https://www.kidney-international.org/article/S0085-2538(24)00717-8/fulltext