Along with iron deficiency, concurrent deficiency of several micronutrients may coexist in school children in India and providing a multi-micronutrient fortified beverage at schools could be effective in reducing the burden of micronutrient deficiencies including iron deficiency and iron deficiency anemia. This study aimed to evaluate the efficacy of a two-month administration of a multi-micronutrient fortified drink in reducing iron deficiency (ID), iron deficiency anemia (IDA) and improving micronutrient status in school children. A two-month, randomized, double-blind, placebo-controlled school-based feeding trial was carried out in Bangalore, India. Iron-depleted 6- to 13-year-old children (N=246) were randomly assigned to either receive a multi-micronutrient fortified drink or an identical unfortified control drink. This study showed that a daily consumption of a multi-micronutrient fortified drink is efficacious in successfully reducing the prevalence of iron deficiency, iron deficiency anemia and significantly improving the micronutrient status in marginally nourished school children.