Authors : Narikot A, Pardeshi VC, Siji A, Raghavendra A, George A, Vasudevan A
Publication Year : 2018
INTRODUCTION:
Previous studies suggest that maternal serum vitamin A levels and polymorphisms in genes regulating vitamin A metabolism may impact fetal kidney development. Information on these genetic variations is limited to Caucasian population.
METHODS:
This prospective observational single center study included newborns of 349 pregnant women enrolled at 8 weeks of gestation. Kidney volumes were measured at birth by ultrasound and cord blood was tested for single nucleotide polymorphisms (SNPs) in genes encoding for aldehyde dehydrogenase 1 family member A2rs7169289, cellular retinoic acid binding protein-2rs12724719, receptor tyrosine kinasers1800860, retinol-binding proteinrs11187540, and the Vitamin A receptor stimulated by retinoic acid 6rs17852249.
RESULTS:
The total (left + right) kidney volume, unadjusted and adjusted for body surface area at birth, was 21.5 [+ or -] 4.6 ml and 107.3 [+ or -] 20.7 ml/m2, respectively. Single nucleotide polymorphisms (SNPs) in genes encoding for proteins regulating vitamin A metabolism were not associated with kidney volume at birth.
CONCLUSIONS:
Polymorphisms in genes involved in vitamin A metabolism are not associated with kidney size in Indian newborns.